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Harvard Case - Synergy Pharmaceuticals Scales Up: License or Go It Alone?

"Synergy Pharmaceuticals Scales Up: License or Go It Alone?" Harvard business case study is written by William A. Andrews. It deals with the challenges in the field of Strategy. The case study is 11 page(s) long and it was first published on : Apr 18, 2019

At Fern Fort University, we recommend that Synergy Pharmaceuticals pursue a strategic alliance with a large pharmaceutical company, leveraging their established infrastructure and global reach to accelerate market penetration and maximize the value of their innovative drug, Plecanatide. This approach balances the benefits of licensing with the control and potential for greater long-term rewards of going it alone.

2. Background

Synergy Pharmaceuticals, a small biotech company, has developed Plecanatide, a promising new drug for the treatment of chronic constipation. The company faces a critical decision: whether to license the drug to a larger pharmaceutical company or pursue commercialization independently.

The case study highlights the company's limited resources, lack of established sales and marketing infrastructure, and the need for significant capital investment to launch Plecanatide effectively. The main protagonists are the company's founders, who must weigh the risks and rewards of each option.

3. Analysis of the Case Study

Porter's Five Forces analysis reveals a highly competitive pharmaceutical industry with strong barriers to entry, intense rivalry, and significant buyer power. The threat of substitutes is moderate, while the bargaining power of suppliers is relatively low.

SWOT Analysis:

Strengths:

  • Innovative drug: Plecanatide offers a potentially significant improvement over existing treatments.
  • Strong clinical data: The drug has demonstrated efficacy and safety in clinical trials.
  • Experienced management team: The founders have a proven track record in the pharmaceutical industry.

Weaknesses:

  • Limited resources: The company lacks the financial resources and infrastructure to launch the drug independently.
  • Lack of marketing expertise: The company has limited experience in marketing and sales.
  • Regulatory hurdles: The drug development process is complex and time-consuming.

Opportunities:

  • Large market potential: The market for constipation treatments is substantial, with a growing elderly population.
  • Potential for partnerships: The company can leverage strategic alliances to access resources and expertise.
  • Emerging markets: The company can expand into new markets with high growth potential.

Threats:

  • Competition: Existing pharmaceutical companies are developing competing drugs.
  • Regulatory changes: The regulatory environment for drug approval is constantly evolving.
  • Economic downturn: A recession could impact drug spending and reduce market demand.

Value Chain Analysis:

Synergy Pharmaceuticals' value chain is focused on drug development and manufacturing. The company lacks a strong distribution and marketing network, which is crucial for commercial success.

Business Model Innovation:

The company's current business model relies on licensing to generate revenue. This strategy is limited in its potential for long-term growth and control. By pursuing a strategic alliance, Synergy Pharmaceuticals can innovate its business model by combining its core competency in drug development with the resources and expertise of a larger partner.

4. Recommendations

Synergy Pharmaceuticals should pursue a strategic alliance with a large pharmaceutical company, ideally one with a strong presence in the gastrointestinal disease market. This approach offers the following advantages:

  • Access to resources: The partner can provide financial resources, marketing expertise, and a global distribution network.
  • Accelerated market penetration: The partner can leverage its existing infrastructure to launch Plecanatide quickly and efficiently.
  • Shared risk and reward: The partnership allows Synergy Pharmaceuticals to share the financial burden and potential rewards of commercialization.

Key considerations for the alliance:

  • Partner selection: The company should carefully evaluate potential partners based on their market reach, expertise in the gastrointestinal disease market, and commitment to the drug's development.
  • Negotiation strategy: The company should negotiate favorable terms that ensure it retains control over the drug's development and marketing.
  • Integration strategy: The company should develop a clear integration plan to ensure a smooth transition and effective collaboration.

5. Basis of Recommendations

This recommendation aligns with Synergy Pharmaceuticals' core competencies in drug development and its mission to deliver innovative treatments to patients. It also considers the company's limited resources, the highly competitive market, and the need for a strong marketing and distribution network.

The alliance approach offers a clear path to market for Plecanatide, maximizing its value and potential for success. It also allows the company to retain some control over the drug's development and marketing, ensuring its long-term viability.

6. Conclusion

By pursuing a strategic alliance, Synergy Pharmaceuticals can leverage the strengths of a larger partner to accelerate market penetration, maximize the value of Plecanatide, and secure its long-term success. This approach offers a balanced solution that addresses the company's current challenges and positions it for future growth.

7. Discussion

Alternative Options:

  • Licensing: While licensing offers a quick and easy path to market, it sacrifices control over the drug's development and marketing. This option also limits the company's potential for long-term growth and profitability.
  • Going it alone: This option is risky and requires significant capital investment. The company's limited resources and lack of marketing expertise make this approach highly challenging.

Risks and Assumptions:

  • Partner selection: Finding the right partner is crucial. A poor choice can lead to conflicts, missed opportunities, and even failure.
  • Negotiation: The company must negotiate favorable terms that protect its interests and ensure its long-term success.
  • Integration: Integrating the two companies' operations and cultures can be challenging.

Key Assumptions:

  • Plecanatide's efficacy and safety: The drug must continue to demonstrate its effectiveness and safety in the market.
  • Market demand: The market for constipation treatments must remain strong and growing.
  • Regulatory approval: The drug must receive regulatory approval in key markets.

8. Next Steps

  • Partner identification: Conduct a thorough evaluation of potential partners based on their market reach, expertise, and commitment to the drug's development.
  • Negotiation: Initiate negotiations with selected partners to secure favorable terms for the alliance.
  • Integration planning: Develop a detailed integration plan to ensure a smooth transition and effective collaboration.
  • Market launch: Prepare for the launch of Plecanatide in key markets, leveraging the partner's resources and expertise.

By taking these steps, Synergy Pharmaceuticals can successfully navigate the challenges of commercializing Plecanatide and position itself for long-term growth and success in the highly competitive pharmaceutical market.

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Case Description

After more than a decade of development, US-based Synergy Pharmaceuticals Inc. (Synergy) received marketing approval from the US Federal Drug Administration (FDA) for its first drug, Trulance, which targeted a large market that had only two other approved competitors. Synergy now needed to scale up from a research-and-development shop to a sales-and-marketing powerhouse. The company had not partnered with a larger pharmaceutical company during the regulatory review process, which was typical for smaller drug development companies, and as a result, it retained 100 per cent of the sales revenue but had virtually no in-house sales or marketing capability. In September 2018, the company was heavily indebted and the stock was priced below US$2; many wondered if Synergy had been right to go it alone or if it should continue that strategy for developing the lucrative North American market. With a new chief executive officer, Trulance sales beginning to accelerate, and other products moving through the FDA approval process, Synergy needed to decide whether to stay the course and become a full-fledged pharmaceutical company or seek a partner and stick to its research and development competency.

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